摘要
背景:脑源性神经营养因子(BDNF)可能通过对基础胆碱能神经元的神经营养作用而在阿尔茨海默病(AD)发病中起关键作用。对AD患者膜降低血清的观察可预测AD的风险。然而,缺乏有关血液中水平因素的知识。 目的:确定血清脑源性神经营养因子水平的临床和人口相关性。 方法:收集1992-1996年和1998-2001之间的参与者,分别从最初的后代Framingham研究组血清测定脑源性神经营养因子。应用标准线性回归和逐步回归模型,分析了临床指标与脑源性神经营养因子水平的关系。在总样本中进行分析,在每个队列中分别进行分析,并按年龄和性别进行调整。 结果:3689名受试者(平均年龄65岁,56%名女性,82%名后代)测定了BDNF。吸烟和高总胆固醇与脑源性神经营养因子水平升高有关,而心房颤动的病史与下降水平有关。BDNF水平升高与后代体力活动和肿瘤坏死因子α水平降低有关。逐步模型也显示他汀类药物的使用、饮酒和载脂蛋白E 4基因型的关联。 结论:血清BDNF与各种代谢、炎症和生活方式相关,这也是导致AD风险的因素。未来血清BDNF的研究与这些风险挂钩,应该调节这些因素和进一步探讨在认知障碍和AD的病理生理BDNF和其他因素之间潜在的相互作用。
关键词: 脑源性神经因子,阿尔兹海默病,队列研究,横断面分析。
Current Alzheimer Research
Title:Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research
Volume: 14 Issue: 7
关键词: 脑源性神经因子,阿尔兹海默病,队列研究,横断面分析。
摘要: Background: Brain derived neurotrophic factor (BDNF) may play a central role in the pathogenesis of Alzheimer's disease (AD) through neurotrophic effects on basal cholinergic neurons. Reduced serum levels of BDND are observed among AD patients and may predict AD risk. Nevertheless, knowledge about factors associated with its levels in blood is lacking.
Objective: To identify clinical and demographic correlates of serum BDNF levels. Methods: BDNF was measured from serum collected between 1992-1996 and 1998-2001 in participants from the Original and Offspring cohorts of the Framingham Study, respectively. A cross-sectional analysis was done to evaluate the relationship between clinical measures and BDNF levels using standard linear regression and stepwise models. Analyses were conducted in the total sample and separately in each cohort, and were adjusted for age and sex. Results: BDNF was measured in 3,689 participants (mean age 65 years, 56% women; 82% Offspring). Cigarette smoking and high total cholesterol were associated with elevated BDNF levels, and history of atrial fibrillation was associated with decreased levels. Elevated BDNF levels were related to greater physical activity and lower Tumor Necrosis Factor-α levels in Offspring. Stepwise models also revealed associations with statin use, alcohol consumption and Apolipoprotein Eε4 genotype. Conclusion: Serum BDNF correlates with various metabolic, inflammatory and life-style measures which in turn have been linked with risk of AD. Future studies of serum BDNF should adjust for these correlates and are needed to further explore the underlying interplay between BDNF and other factors in the pathophysiology of cognitive impairment and AD.Export Options
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Cite this article as:
Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research, Current Alzheimer Research 2017; 14 (7) . https://dx.doi.org/10.2174/1567205014666170203094520
DOI https://dx.doi.org/10.2174/1567205014666170203094520 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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