TXNIP代谢调节：生理作用和治疗前景

Title:TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

Volume: 18 Issue: 9

关键词: 糖尿病，硫氧还蛋白系统，硫氧还蛋白相互作用蛋白，氧化应激，胰岛素抵抗，胰腺β细胞功能障碍，代谢稳态

摘要: Background & Objective: Thioredoxin-interacting protein (TXNIP) also known as thioredoxin binding protein-2 is a ubiquitously expressed protein that interacts and negatively regulates expression and function of Thioredoxin (TXN). Over the last few years, TXNIP has attracted considerable attention due to its wide-ranging functions impacting several aspects of energy metabolism. TXNIP acts as an important regulator of glucose and lipid metabolism through pleiotropic actions including regulation of β-cell function, hepatic glucose production, peripheral glucose uptake, adipogenesis, and substrate utilization. Overexpression of TXNIP in animal models has been shown to induce apoptosis of pancreatic β-cells, reduce insulin sensitivity in peripheral tissues like skeletal muscle and adipose, and decrease energy expenditure. On the contrary, TXNIP deficient animals are protected from diet induced insulin resistance and type 2 diabetes.

Cite this article as:

TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook, Current Drug Targets 2017; 18 (9) . https://dx.doi.org/10.2174/1389450118666170130145514