摘要
背景：动脉粥样硬化（AS）是西方世界的死亡和致残的主要原因，是与致动脉粥样化脂蛋白和炎症密切相关。胆汁酸（BA）作为激活内源性配体如法尼基-X受体（FXR）信号。初步数据表明FXR的潜在作用，但FXR配体在AS中的治疗价值是未知的。 目的：本综述，分析了FXR激动剂作为一种治疗方式的疗效对。在这方面，我们进行电子搜索通过Pub- Med/MEDLINE数据库使用的关键术语：受体，动脉粥样硬化，胆汁酸和激动 。 结论：根据我们的分析，FXR似乎是动脉粥样硬化自然史上有希望的治疗靶点。FXR激动可以在AS的发展和发展中发挥保护作用。 然而，FXR激动存在已经报道的副作用，例如血浆HDL的降低。最后，使用合成FXR激动剂进行临床试验的结果将更多地反映FXR激动在AS治疗中的确切作用。
关键词: FXR，动脉粥样硬化，激动剂，胆汁酸，药物靶标，临床试验。
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Analytical Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Related Books
test ebook
COVID-19: Causes, Transmission, Diagnosis, and Treatment
2-Deoxy-D-Glucose: Chemistry and Biology
Chiral Ionic Liquids: Applications in Chemistry and Technology
Anthocyanins: Pharmacology and Nutraceutical Importance
Herbal Medicine for Autoimmune Diseases
Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules
Computer-Aided Drug Discovery Methods: A Brief Introduction
The Roles and Responsibilities of Clinical Pharmacists in Hospital Settings
Bioactive Compounds from Medicinal Plants for Cancer Therapy and Chemoprevention
81
18
1
2