Lipoprotein (a) Evolution: Possible Benefits and Harm. Genetic and Non-Genetic Factors Influencing its Plasma Levels

Title:Lipoprotein (a) Evolution: Possible Benefits and Harm. Genetic and Non-Genetic Factors Influencing its Plasma Levels

Volume: 24 Issue: 10

Author(s): Peggy M. Kostakou, George Hatzigeorgiou, Vana Kolovou, Sophie Mavrogeni and Genovefa D. Kolovou*

Affiliation:

• Outpatient Clinics and LDL Apheresis Unit, Onassis Cardiac Surgery Center, 356 Sygrou Ave 176 74, Athens,Greece

Keywords: Lipoprotein (a), evolution, genetic factor, race, gender, hormones, drugs.

Abstract: The limited distribution of lipoprotein (a) (Lp(a)) to humans, Old World primates and to the European hedgehog, has raised considerable interest and speculation regarding its possible physiological role. Lp(a) has variable circulating concentrations (<0.1 – >100 mg/ml) which are highly genetically determined in humans. These characteristics gave rise to several theories concerning the origins and evolution of Lp(a). Lp(a) has a protective role after injury since Lp(a) particles bind to macrophages and platelets membrane receptors, leading to fibrin activation and injury healing. On the other hand, Lp(a) seems to be implicated in the formation of atheromatic plaques but also in cerebrovascular events and stenosis of the aortic valve.

Cite this article as:

Kostakou M. Peggy, Hatzigeorgiou George, Kolovou Vana, Mavrogeni Sophie and Kolovou D. Genovefa*, Lipoprotein (a) Evolution: Possible Benefits and Harm. Genetic and Non-Genetic Factors Influencing its Plasma Levels, Current Medicinal Chemistry 2017; 24 (10) . https://dx.doi.org/10.2174/0929867324666170120155412