Natural AMPK Activators: An Alternative Approach for the Treatment and Management of Metabolic Syndrome

Title:Natural AMPK Activators: An Alternative Approach for the Treatment and Management of Metabolic Syndrome

Volume: 24 Issue: 10

Author(s): Hitender Sharma and Sunil Kumar*

Affiliation:

• Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana,India

Keywords: Cardiovascular disorders, diabetes, obesity, metabolic syndrome, transcription factors, phytoconstituents.

Abstract: This review covers recent discoveries of phytoconstituents, herbal extracts and some semi-synthetic compounds for treating metabolic syndrome with AMPK activation as one of their mechanisms of action. Recent researches have demonstrated AMPK activation to ameliorate multiple components of metabolic syndrome by regulating a balance between anabolic and catabolic cellular reactions. The review attempts to delineate the AMPK activation by natural agents from the perspective of its functional consequences on enzymes, transcription factors and signaling molecules and also on other potential factors contributing in the amelioration of metabolic syndrome.

Cite this article as:

Sharma Hitender and Kumar Sunil*, Natural AMPK Activators: An Alternative Approach for the Treatment and Management of Metabolic Syndrome, Current Medicinal Chemistry 2017; 24 (10) . https://dx.doi.org/10.2174/0929867323666160406120814