Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review

Title:Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review

Volume: 21 Issue: 12

Author(s): Chukwuebuka Egbuna*, Chinaza G. Awuchi, Garima Kushwaha, Mithun Rudrapal, Kingsley C. Patrick-Iwuanyanwu, Omkar Singh, Uchenna E. Odoh, Johra Khan, Jaison Jeevanandam, Suresh Kumarasamy, Vincent O. Chukwube, Mathiyazhagan Narayanan, Santwana Palai, Mihnea-Alexandru Găman, Chukwuemelie Z. Uche, Daprim S. Ogaji, Nebechi J. Ezeofor, Andrew G. Mtewa, Chinyere C. Patrick-Iwuanyanwu, Shyam S. Kesh, Chandan Shivamallu, Kaliyaperumal Saravanan, Habibu Tijjani, Muhammad Akram, Jonathan C. Ifemeje, Michael C. Olisah and Chukwudi J. Chikwendu

Affiliation:

• World Bank Africa Centre of Excellence in Public Health and Toxicological Research (PUTOR), University of Port-Harcourt, Rivers State,Nigeria

Keywords: Type 2 diabetes, (T2DM), Anti-diabetic agents, Bioactive compounds, Phytochemicals, Medicinal plants, Polyphenols, Flavonoids.

Abstract:

Background: Type 2 diabetes (adult onset diabetes) is the most common type of diabetes, accounting for around 90% of all diabetes cases with insulin resistance and insulin secretion defect. The key goal of anti-diabetic therapy is to increase the development of insulin, immunity and/or decrease the amount of blood glucose. While many synthetic compounds have been produced as antidiabetic agents, due to their side effects and limited effectiveness, their usefulness has been hindered.

Methods: This systematic review investigated the bioactive compounds reported to possess activities against type 2 diabetes. Three (3) databases, PubMed, ScienceDirect and Google Scholar were searched for research articles published between January 2010 and October 2020. A total of 6464 articles were identified out of which 84 articles were identified to be elligible for the study.

Result and Discussion: From the data extracted, it was found that quercetin, Kaempferol, Rosmarinic acid, Cyanidin, Rutin, Catechin, Luteolin and Ellagic acid were the most cited bioactive compounds which all falls within the class of polyphenolic compounds. The major sources of these bioactive compounds includes citrus fruits, grapes, onions, berries, cherries, broccoli, honey, apples, green tea, Ginkgo biloba, St. John's wort, green beans, cucumber, spinach, tea, Rosmarinus officinalis, Aloe vera, Moringa oleifera, tomatoes, potatoes, oregano, lemon balm, thyme, peppermint, Ocimum basilicum, red cabbage, pears, olive oil and walnut.

Cite this article as:

Egbuna Chukwuebuka*, Awuchi G. Chinaza, Kushwaha Garima, Rudrapal Mithun, Patrick-Iwuanyanwu C. Kingsley, Singh Omkar, Odoh E. Uchenna, Khan Johra, Jeevanandam Jaison, Kumarasamy Suresh, Chukwube O. Vincent, Narayanan Mathiyazhagan, Palai Santwana, Găman Mihnea-Alexandru, Uche Z. Chukwuemelie, Ogaji S. Daprim, Ezeofor J. Nebechi, Mtewa G. Andrew, Patrick-Iwuanyanwu C. Chinyere, Kesh S. Shyam, Shivamallu Chandan, Saravanan Kaliyaperumal, Tijjani Habibu, Akram Muhammad, Ifemeje C. Jonathan, Olisah C. Michael and Chikwendu J. Chukwudi, Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review, Current Topics in Medicinal Chemistry 2021; 21 (12) . https://dx.doi.org/10.2174/1568026621666210509161059