天然1,4-苯醌醌及其（半）合成衍生物的化学和生物学方面

Title:Chemical and Biological Aspects of the Natural 1,4-Benzoquinone Embelin and its (semi-)Synthetic Derivatives

Volume: 24 Issue: 18

关键词: 天竺葵，天然产物，苯醌，抗氧化剂，药物设计，（半））合成丝氨酸衍生物

摘要: Background: Like the impressive biological properties of embelin, its chemical aspects have raised the interest of scientists in the field as well. A detailed understanding of the chemistry of embelin is necessary to fully exploit it medicinally.

Methods: Search for embelin isolation and its chemical modifications was carried out using web-based literature searching tools such as Pubmed and Scifinder. Pertinent literature is covered up to 2016. Structures of bioactive embelin derivatives are provided.

Results: Pure embelin, obtained from Embelia ribes berries extraction or by total synthesis, was applied for a number of biological assays. Semi-synthetic and total synthetic approaches led to new high affinity embelin-derived inhibitors of crucial protein targets and to new embelin derivatives with improved pharmacological properties (e.g., with better water-solubility or as applications for drug carrier systems).

Conclusion: This review provides a summary of the rich chemistry of embelin and the latest developments in the field of optimized (semi-)synthetic embelin derivatives including their biological activities.

Cite this article as:

Chemical and Biological Aspects of the Natural 1,4-Benzoquinone Embelin and its (semi-)Synthetic Derivatives, Current Medicinal Chemistry 2017; 24 (18) . https://dx.doi.org/10.2174/0929867324666170116125731

DOI https://dx.doi.org/10.2174/0929867324666170116125731	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X