CEBP表观遗传调节作为治疗血液和妇科恶性肿瘤的药物靶点

Title:CEBP Epigenetic Dysregulation as a Drug Target for the Treatment of Hematologic and Gynecologic Malignancies

Volume: 18 Issue: 10

关键词: CCAAT /增强子结合蛋白，C / EBP，妇科癌症，血液恶性肿瘤，高甲基化，表观遗传调节异常

摘要: Background: The CCAAT/enhancer binding proteins (C/EBPs) form a family of transcription factors regulating many genes’ expression in a variety of cells/tissues/organs at different developmental stages. With their capability of binding to their cognate DNA elements and through protein-protein interactions, C/EBPs modulate diverse functions including cell differentiation, metabolism, and immune response, under both physiological and pathological conditions such as the establishment of hematological lineages, the maintenance of normal reproductive function, and the development of malignancies.

Objectives: This review concentrates on the role(s) and epigenetic alterations of C/EBP genes in hematologic malignancies and gynecologic organs and disorders. New research findings on molecular pathways involved in C/EBP function and regulation are reviewed and analyzed. The potential therapeutic values of these findings are also discussed.

Conclusion: Unlike in hematologic malignancies in which C/EBP mutations and their disruption of wild type C/EBP tumor suppressive activities have been well documented, mutation of C/EBP does not appear to be a common event in gynecologic cancers, raising some doubt if C/EBPs may have tumor suppressor activity in gynecologic cancers. However, this notion could not exclude the possibility that downregulation or DNA methylation-meditated epigenetic silencing of C/EBPs may contribute to the development of gynecologic malignancies.

Cite this article as:

CEBP Epigenetic Dysregulation as a Drug Target for the Treatment of Hematologic and Gynecologic Malignancies, Current Drug Targets 2017; 18 (10) . https://dx.doi.org/10.2174/1389450117666161228160455

DOI https://dx.doi.org/10.2174/1389450117666161228160455	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592