Targeting Apoptosis Pathways in Cancer Therapy

Title: Targeting Apoptosis Pathways in Cancer Therapy

Volume: 4 Issue: 7

Author(s): Simone Fulda and Klaus-Michael Debatin

Affiliation:

Keywords: apoptosis, cancer, mitochondria, cancer therapy, resistance

Abstract: Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, e.g. chemotherapy, γ-irradiation, immunotherapy or suicide gene therapy, is predominantly mediated by triggering apoptosis, the cells intrinsic death program. Accordingly, defects in apoptosis pathways can result in cancer resistance to current treatment approaches. Understanding the molecular mechanisms that regulate cell death programs including apoptosis, and how resistant forms of cancer evade apoptotic events, may provide novel opportunities for cancer drug development.

Cite this article as:

Fulda Simone and Debatin Klaus-Michael, Targeting Apoptosis Pathways in Cancer Therapy, Current Cancer Drug Targets 2004; 4 (7) . https://dx.doi.org/10.2174/1568009043332763