Glucocorticoid Receptor Interacting Co-regulators: Putative Candidates for Future Drug Targeting Therapy

Title:Glucocorticoid Receptor Interacting Co-regulators: Putative Candidates for Future Drug Targeting Therapy

Volume: 17 Issue: 8

Author(s): Alessia Di Silvestre, Marianna Lucafo, Sara De Iudicibus, Alessandro Ventura, Stefano Martelossi, Gabriele Stocco and Giuliana Decorti*

Affiliation:

• Department of Life Sciences, University of Trieste, Via Alexander Fleming, 22, 34127 Trieste,Italy

Keywords: Biomarkers, epigenetic, glucocorticoid, glucocorticoid receptor, protein-protein interactions, RNA-protein interactions, sensitivity.

Abstract: Background: Glucocorticoids (GCs) are largely used in different inflammatory, autoimmune and proliferative diseases. To date their mechanism of action is not completely clear and more studies are necessary, in particular to explain the great interindividual variability in clinical response. In this panorama the glucocorticoid receptor (GR) has an important role: in fact it regulates the pharmacological response thanks to the capability to interact with different molecules (DNA, RNA, ncRNA and proteins) that are known to influence its activity.

Cite this article as:

Di Silvestre Alessia, Lucafo Marianna, De Iudicibus Sara, Ventura Alessandro, Martelossi Stefano, Stocco Gabriele and Decorti Giuliana*, Glucocorticoid Receptor Interacting Co-regulators: Putative Candidates for Future Drug Targeting Therapy, Mini-Reviews in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1389557516666161130094255