Hypersensitivity Reactions from Excipients in Systemic Glucocorticoid Formulations

Title:Hypersensitivity Reactions from Excipients in Systemic Glucocorticoid Formulations

Volume: 15 Issue: 2

Author(s): Gianfranco Calogiuri, Lene H. Garvey, Paolo Romita, Luigi Macchia and Caterina Foti

Affiliation:

Keywords: Anaphylaxis, carboxymethylcellulose, excipients, glucocorticoids, hypersensitivity, lactose, macrogols, povidone.

Abstract: Glucocorticoids are the most widely used drugs for the treatment of hypersensitivity, however these drugs themselves and the excipients contained in commercial corticosteroid formulations are able to induce severe immediate-type hypersensitivity reactions. Reactions involving excipients have been confirmed to be IgE mediated by the demonstration of specific-IgE to excipients such as carboxymethylcellulose and lactose. In case of hypersensitivity reactions to corticosteroid preparations, a complete allergy work-up with skin tests and/or challenge tests should include testing excipients as well as the active ingredients.

Cite this article as:

Calogiuri Gianfranco, Garvey H. Lene, Romita Paolo, Macchia Luigi and Foti Caterina, Hypersensitivity Reactions from Excipients in Systemic Glucocorticoid Formulations, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2016; 15 (2) . https://dx.doi.org/10.2174/1871523016666161109144021