植物化学物质治疗阿尔茨海默病：系统评价

Title:Phytochemicals in the Treatment of Alzheimer’s Disease: A Systematic Review

Volume: 18 Issue: 13

关键词: 植物化学物质，阿尔茨海默病，抗氧化性能，抗炎活性，乙酰胆碱酯酶抑制剂，AChEIs

摘要: Background: Alzheimer's disease (AD) is the most widespread age-related neurodegenerative disease. Recently, a growing body of evidence suggested the phytochemical use to slow down AD onset and progression.

Objective: To review the phytochemical role potentially involved in AD treatment.

Method: A systematic review from existing literature on phytochemicals used in the treatment of AD patients was conducted. Selection criteria included: 1) age≥60 years; 2) AD diagnosis in agreement with the criteria of National Institute on Aging-Alzheimer's Association (NIAAA), and 3) suitable measures to asses cognitive, functional and clinical status.

Results: Ninety-seven articles were involved in the present study. Several phytochemicals seem to slow down AD onset, delay disease progression and let recovery through targeting multiple pathological causes by anti-cholinergic, antioxidant and anti-inflammatory features.

Conclusion: Deeper knowledge on phytochemicals and their specific molecular targets is essential to guarantee safe use of these compounds as an option for AD treatment.

Cite this article as:

Phytochemicals in the Treatment of Alzheimer’s Disease: A Systematic Review, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161102121553

DOI https://dx.doi.org/10.2174/1389450117666161102121553	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592