Recent Advances of Metallocenes for Medicinal Chemistry

Title:Recent Advances of Metallocenes for Medicinal Chemistry

Volume: 17 Issue: 9

Author(s): Miguel M. Santos*, Pedro Bastos, Isabelle Catela, Karolina Zalewska and Luis C. Branco*

Affiliation:

• LAQV-REQUIMTE, Chemistry Department, Faculty of Science and Technology, Universidade NOVA de Lisboa, P.O. Box: 2829-516,Portugal

• LAQV-REQUIMTE, Chemistry Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da FCT/UNL,Portugal

Keywords: Anti-HIV, anti-malaria, anti-tumoral, ferrocene derivatives, medicinal chemistry, metallocenes.

Abstract: Background: The recent advances for the synthesis and application of different metallocenes for Medicinal Chemistry is reviewed.

Objective: This manuscript presents the different metallocene scaffolds, with special emphasis on ferrocene derivatives, and their potential pharmaceutical application. Over the last years, the synthesis of new metallocene compounds and their biological and medicinal effects against some types of diseases (e.g. anti-tumoral, antibiotics, anti-viral) have been reported. From the medicinal point of view, the attractive properties of metallocene derivatives, such as their high stability, low toxicity and appealing redox behaviors are particularly relevant.

Results: This area has attracted many researchers as well as the pharmaceutical industry due to the promising results of some metallocenes, in particular ferrocene compounds, in breast cancer and malaria.

Cite this article as:

Santos M. Miguel*, Bastos Pedro, Catela Isabelle, Zalewska Karolina and Branco C. Luis*, Recent Advances of Metallocenes for Medicinal Chemistry, Mini-Reviews in Medicinal Chemistry 2017; 17 (9) . https://dx.doi.org/10.2174/1389557516666161031141620

DOI https://dx.doi.org/10.2174/1389557516666161031141620	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607