Severe Coagulation Disorder and Thrombocytopenia Associated with Tigecycline – Case Report and Review of Literature

Sami      Giryes; Zaher   S.   Azzam; Reem      Ismael-Badarneh; Norberto      Krivoy; Gidon      Berger

doi:10.2174/1574886311666160920090714

Abstract

Herein, we report a 70-year-old male patient, with recurrent multiple hepatic abscesses, that was admitted to the internal medicine department for treatment of Carbapenem Resistant Escherichia Coli (CRE) bacteremia.

The patient was treated with Tigecycline; few days later, he developed "Disseminated Intravascular Coagulation (DIC)" like coagulation study abnormality that seemed to be related to Tigecycline treatment. Upon discontinuing it, the DIC-like condition was resolved.

Tigecycline should be considered as a possible etiological factor in patients with DIC-like, and this therapy should be withdrawn immediately in suspected cases.

Keywords: Coagulation disorder, DIC, hypofibrinogenemia, Tigecycline, thrombocytopenia.

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DOI https://dx.doi.org/10.2174/1574886311666160920090714	Print ISSN 1574-8863
Publisher Name Bentham Science Publisher	Online ISSN 2212-3911

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Severe Coagulation Disorder and Thrombocytopenia Associated with Tigecycline – Case Report and Review of Literature

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