多形性成胶质瘤细胞的新方法：免疫检查点抑制剂的潜在作用

Title:New Approaches in Glioblastoma Multiforme: The Potential Role of Immune- check Point Inhibitors

Volume: 17 Issue: 3

关键词: 免疫治疗，多形性成胶质瘤细胞，检查点，放疗，PD-1，CTLA-4，ipilimumab

摘要: Background: Glioblastoma multiforme (GBM) is the most frequent brain tumor. Despite recent advances in treatment approaches the prognosis remains poor, with a median overall survival of 14.6 months. Immunotherapy is the subject of ongoing research and its benefit is becoming evident in other malignancies. Immune check-points such as cytotoxic T lymphocyte associated antigen 4 (CTLA-4), programmed cell death receptor (PD-1) and indoleamine 2,3-dioxygenase (IDO) reduce immune response.

Cite this article as:

New Approaches in Glioblastoma Multiforme: The Potential Role of Immune- check Point Inhibitors, Current Cancer Drug Targets 2017; 17 (3) . https://dx.doi.org/10.2174/1568009616666160813183738