生物碱作为一种新的治疗靶点的抗真菌作用

Title:Antifungal Potential of Alkaloids As An Emerging Therapeutic Target

Volume: 18 Issue: 16

关键词: 生物碱，抗真菌活性，结构和效力，抗真菌药物，机制，替代药物，未来的药物。

摘要: Background: Fungal infections have been causing serious problems in all age groups, especially in immune-compromised individuals. Various synthetic agents are in clinical practice for the treatment of these infections, however, resistance to these agents badly affected their therapeutic quality.

Objective: This review focuses on the antifungal activity of naturally occurring alkaloids, their source, chemical structure, and potency with a possible mechanism(s) of action.

Results: The results of available literature showed that at least 70 different plant derived alkaloids exhibited antifungal activity in vitro. These alkaloids are isolated from different plants and families showing their diverse distribution in plant kingdom. Additionally, the alkaloid from various classes depicted antifungal effects against a variety of fungi.

Conclusions: Alkaloids could be a better therapeutic alternative to available therapies with fewer chances of resistance but more research and clinical trials are needed before final recommendations. Additionally, the details provided in this review will offer greater awareness of the excellent promise that natural alkaloids exhibit as antifungal agents.

Cite this article as:

Antifungal Potential of Alkaloids As An Emerging Therapeutic Target, Current Drug Targets 2017; 18 (16) . https://dx.doi.org/10.2174/1389450117666160719095517