A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

Title:A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

Volume: 12 Issue: 5

Author(s): Sharon Lai-Fung Chan, Lihua Lu, Tsz Lung Lam, Siu-Cheong Yan, Chung-Hang Leung and Dik-Lung Ma

Affiliation:

Keywords: 2-acetylbenzo[b]thiophen-3-olate, Alzheimer's disease, beta-amyloid, ruthenium(II), tris(2-pyridylmethyl)amine.

Abstract: We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO₄ 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.

Cite this article as:

Chan Lai-Fung Sharon, Lu Lihua, Lam Lung Tsz, Yan Siu-Cheong, Leung Chung-Hang and Ma Dik-Lung, A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation, Current Alzheimer Research 2015; 12 (5) . https://dx.doi.org/10.2174/1567205012666150504150726