Energy Remodeling, Mitochondrial Disorder and Heart Failure

Title:Energy Remodeling, Mitochondrial Disorder and Heart Failure

Volume: 22 Issue: 31

Author(s): Peng Wang, Lei Xu and Aijun Sun

Affiliation:

Keywords: Energy metabolism, mitochondrial disorder, heart failure.

Abstract: Heart failure (HF) is a major global problem in public health with no curative treatment currently available. Energy remodeling is one of the features in HF, preceding cardiac structure remodeling. As an important energy organelle, mitochondrion plays critical roles in the progress of HF. This review focuses on the potential mechanisms linking mitochondrial functions and energy remodeling in HF including the energy starvation theory and energy substrate metabolism. It also highlights the potentials of novel drugs targeting HF energy metabolism.

Cite this article as:

Wang Peng, Xu Lei and Sun Aijun, Energy Remodeling, Mitochondrial Disorder and Heart Failure, Current Pharmaceutical Design 2016; 22 (31) . https://dx.doi.org/10.2174/1381612822666160708224330