知识转化的层次：从健康问题到特殊药物设计

Title:Hierarchy of Knowledge Translation: From Health Problems to Ad-Hoc Drug Design

Volume: 23 Issue: 26

Author(s): David Fajardo and Victor M. Castano

Affiliation:

关键词: 生物医学知识，转化中心，交易区，科学文化。

摘要: An innovative approach to analyze the complexity of translating novel molecular entities and nanomaterials into pharmaceutical alternatives (i.e., knowledge translation, KT) is discussed. First, some key concepts on the organization and translation of the biomedical knowledge (paradigms, homophily, power law distributions, hierarchy, modularity, and research fronts) are reviewed. Then, we propose a model for the knowledge translation (KT) in Drug Discovery that considers the complexity of interdisciplinary communication.

Specifically, we address two highly relevant aspects: 1) A successful KT requires the emergence of organized bodies of inter-and transdisciplinary research, and 2) The hierarchical and modular topological organization of these bodies of knowledge. We focused on a set of previously-published studies on KT which rely on a combination of network analysis and computer-assisted analysis of the contents of scientific literature and patents. The selected studies provide a duo of complementary perspectives: the demand of knowledge (cervical cancer and Ebola hemorrhagic fever) and the supply of knowledge (liposomes and nanoparticles to treat cancer and the paradigmatic Doxil, the first nano- drug to be approved).

Cite this article as:

David Fajardo and Victor M. Castano , Hierarchy of Knowledge Translation: From Health Problems to Ad-Hoc Drug Design, Current Medicinal Chemistry 2016; 23 (26) . https://dx.doi.org/10.2174/0929867323666160617101823