神经酰胺和Sphingosine-1-Phosphate细胞死亡途径:与阿尔茨海默病的发病机制之间的关系

Title:Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease

Volume: 13 Issue: 11

Author(s): Sankha Shubhra Chakrabarti, Aritri Bir, Jit Poddar, Maitrayee Sinha, Anirban Ganguly, Sasanka Chakrabarti

Affiliation:

关键词: 鞘磷脂、神经酰胺、Sphingosine-1-phosphate、线粒体淀粉样β蛋白、细胞凋亡、Necroptosis、阿尔茨海默氏症。

摘要: The metabolic turnover of sphingolipids produces several signaling molecules that profoundly affect the proliferation, differentiation and death of cells. In particular, an enormous body of information is available that defines the varied role of ceramide and sphingosine-1-phosphate in cell death and survival. This review specifically examines the role of ceramide and sphingosine-1- phosphate in triggering neuronal death in Alzheimer's disease by analyzing the data from post-mortem studies and experimental research. There is compelling evidence that ceramide plays a key role in the neurodegeneration and amyloidogenesis occurring in the brain in Alzheimer's disease. Further, it appears that ceramide and amyloid beta protein orchestrate an attack on mitochondria to set in the pathways of cell death. However, the complexity of metabolic and signaling pathways of sphingolipid derivatives precludes an immediate identification of effective drug targets for the therapy of Alzheimer's disease.

Cite this article as:

Sankha Shubhra Chakrabarti, Aritri Bir, Jit Poddar, Maitrayee Sinha, Anirban Ganguly, Sasanka Chakrabarti , Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease, Current Alzheimer Research 2016; 13 (11) . https://dx.doi.org/10.2174/1567205013666160603004239