Role of Brain NUCB2/nesfatin-1 in the Stress-induced Modulation of Gastrointestinal Functions

Title:Role of Brain NUCB2/nesfatin-1 in the Stress-induced Modulation of Gastrointestinal Functions

Volume: 14 Issue: 8

Author(s): Miriam Goebel-Stengel and Andreas Stengel

Affiliation:

Keywords: Brain-gut axis, corticotropin releasing factor, CRF, food intake, motility, secretion.

Abstract: Background: Nucleobindin2 (NUCB2)/nesfatin-1 plays a well-established role in homeostatic functions associated with food intake and stress integration.

Aim: This review focusses on NUCB2/nesfatin-1’s central effects on gastrointestinal functions and will summarize the effects on food intake, motility and secretion with focus on the upper gastrointestinal tract.

Results: We will highlight the stressors that influence brain NUCB2/nesfatin-1 expression and discuss functional implications. In addition to traditional acute psychological and physical stressors such as restraint stress and abdominal surgery we will look at immunological, visceral and metabolic stressors as well as a chronic combination stress model that have been shown to affect NUCB2/nesfatin-1 signaling and describe associated functional consequences.

Cite this article as:

Goebel-Stengel Miriam and Stengel Andreas, Role of Brain NUCB2/nesfatin-1 in the Stress-induced Modulation of Gastrointestinal Functions, Current Neuropharmacology 2016; 14 (8) . https://dx.doi.org/10.2174/1570159X14666160601153202