Abstract
The Diels-Alder cycloaddition is one of the most utilized reactions for the construction of cyclic systems with high regio-, chemo- and stereoselectivity. Accordingly, this versatile reaction has been broadly exploited in synthetic organic chemistry for the transformation of natural products, structurally diverse molecules of biological interests, pharmaceuticals, polymers and new materials. Nature has also used this cycloaddition reaction and Diels Alderase enzymes were proposed in many biosynthetic pathways of secondary metabolites. The aim of this account is to furnish to the scientific community an overview of reactions using a Diels Alderase for natural product biosynthesis. The proposed biosynthetic pathways involving Diels-Alder reaction are also summarized.
Keywords: Natural products, biosynthesis, putative, Diels-Alder reaction.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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