Abstract
Different synthetic strategies to 4,4-disubstituted pyridazines and condensed pyridazines with a special reference to the synthetic routes to their spiro analogues are comprehensively outlined in this review.
Keywords: Spirocyclic pyridazines, partially-saturated pyridazines, synthesis, retro- Diels-Alder, 1, 3-dipolar cycloaddition, Aza-Michael addition, nucleophilic reactions.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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