Hepatitis C Virus-Associated B-Cell Non-Hodgkin's Lymphoma: Clinical and Therapeutic Challenges

Title:Hepatitis C Virus-Associated B-Cell Non-Hodgkin's Lymphoma: Clinical and Therapeutic Challenges

Volume: 18 Issue: 7

Author(s): Sabino Russi, Loredana Sansonno and Domenico Sansonno*

Affiliation:

• Liver Unit, Department of Internal Medicine and Human Oncology, University of Bari Medical School, Policlinico - Piazza Giulio Cesare, 11 - 70124 Bari,Italy

Keywords: Hepatitis C virus, B-cell non-hodgkin’s lymphoma, lymphomagenesis, lymphoproliferation, mixed cryoglobulinemia, vasculitis.

Abstract: Hepatitis C virus (HCV) is a major cause of liver-related morbidity and is strongly associated with B-cell lymphoproliferative disorders. Data from epidemiological, biological and clinical investigations support the hypothesis of a pathogenetic role of HCV in at least a subgroup of patients with B-cell non-Hodgkin’s lymphoma (B-NHL). Morphologically, HCV-associated B-NHL represents a variety of histological subtypes. The comprehension of the mechanisms of HCV persistence and of its role in the lymphomagenesis will be useful to set new strategies with the aim to prevent and treat HCV-associated B-NHLs. This hypothesis of a virus-induced mechanism of lymphomagenesis arises from the growing evidence that successful antiviral treatment is often linked to regression of some types of HCV-related indolent B-NHLs.

Cite this article as:

Russi Sabino, Sansonno Loredana and Sansonno Domenico*, Hepatitis C Virus-Associated B-Cell Non-Hodgkin's Lymphoma: Clinical and Therapeutic Challenges, Current Drug Targets 2017; 18 (7) . https://dx.doi.org/10.2174/1389450117666160201112525