Synthesis and Some Reactions of 1-aryl-4-acetyl-5-methyl-1,2,3-triazole Derivatives with Anticonvulsant Activity

Title:Synthesis and Some Reactions of 1-aryl-4-acetyl-5-methyl-1,2,3-triazole Derivatives with Anticonvulsant Activity

Volume: 16 Issue: 11

Author(s): Ekhlass M. Nassar, Fathy M. Abdelrazek, Rezk R. Ayyad and Ahmed F. El-Farargy

Affiliation:

Keywords: Anticonvulsant activity, chalcones, diazepines, hydrazino-pyrimidines, pyrimidine-thioles, 1, 2, 3-triazoles, ultrasonication.

Abstract: The triazoles 3a-d underwent condensation reactions with 4-(piperidin-1-yl)-benzaldehyde to afford the chalcones 5a-d. Chalcone derivatives 5a-d were reacted with 2,3-diaminomaleonitrile, thiourea and hydrazine hydrate to afford the novel diazepine-dicarbonitrile derivatives 7a-d, the pyrimidine-2-thiol derivatives 9a-d and hydrazino-pyrimidines 10a-d respectively. Structures of the prepared compounds were elucidated by physical and spectral data like FT-IR, ¹H NMR, ¹³C NMR, and mass spectroscopy. Some of the synthesized compounds were screened for their anticonvulsant activity and SAR.

Cite this article as:

M. Nassar Ekhlass, M. Abdelrazek Fathy, R. Ayyad Rezk and F. El-Farargy Ahmed, Synthesis and Some Reactions of 1-aryl-4-acetyl-5-methyl-1,2,3-triazole Derivatives with Anticonvulsant Activity, Mini-Reviews in Medicinal Chemistry 2016; 16 (11) . https://dx.doi.org/10.2174/1389557516666160118105505