摘要
Pristimerin是一种天然三萜类化合物属于美登木属和南蛇藤属,已被证明具有多种生物和药理作用。最近,扁塑藤素吸引了更多的关注,特别是对其潜在的抗癌活性。扁塑藤素的抗癌活动已经在各种癌症细胞株和动物模型得到证明。人们已经发现它抑制体外和体内肿瘤细胞增殖,生存,血管生成和肿瘤细胞的转移。这些活动一直归因于其调制各种分子的目标细胞周期蛋白,如细胞凋亡相关蛋白,蛋白酶体活动,活性氧物种,以及NF-κB AKT / mTOR和MAPK / ERK途径。本文着重讨论了扁塑藤素治疗对细胞的影响和动物研究,更多的关注Pristimerin的各种分子靶点。
关键词: 抗肿瘤药物，天然产物，转录因子蛋白族，药理活性，pristimerin
图形摘要
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