摘要
在过去的几十年里,局部和透皮给药已被研究,它呈现了对一些严重疾病治疗,大分子传递和疫苗接种的治疗优势。最大的挑战是克服角质层(SC)屏障。相比传统的外用制剂纳米/微提供策略,如增加稳定性的优点,增加负荷量,不受欢迎的颜色覆盖,降低毒性和活性剂延长释放。然而,有没有确凿的研究表明,这样的系统的能力,渗透在有关的治疗量的皮肤。使用物理方法有很大的潜力,加强皮肤渗透,通过供应链和针对毛囊。本文综述了与使用双方法采用渗透增强的物理方法使局部或透皮给药的纳米/微系统应用的可行性的特点。
关键词: 树枝状聚合物,离子导入,脂质体,微针,纳米颗粒,渗透皮肤,超音波。
图形摘要
Current Drug Targets
Title:Topical and Transdermal Delivery of Drug-Loaded Nano/ Microsystems with Application of Physical Enhancement Techniques
Volume: 17 Issue: 13
Author(s): Lívia Neves Borgheti-Cardoso, Tamara Ângelo, Guilherme M. Gelfuso, Renata F.V. Lopez, Taís Gratieri
Affiliation:
关键词: 树枝状聚合物,离子导入,脂质体,微针,纳米颗粒,渗透皮肤,超音波。
摘要: Topical and transdermal delivery has been studied over last decades and it presents advantages for the treatment of several disorders, macromolecules delivery and vaccination. The greatest challenge is to overcome the stratum corneum (SC) barrier. Compared to traditional topical formulation strategies, nano /microsystems offer advantages such as increased stability, increased loading dose, coverage of undesired colors, reduced toxicity and prolonged release of active agents. However, there are no conclusive studies demonstrating the ability of such systems to penetrate the skin in relevant therapeutic amounts. The use of physical methods holds great promise for enhancing skin permeation through the SC and for targeting hair follicles. This review discusses the characteristics and feasibility of using a dual approach employing the application of physical methods of permeation enhancement to enable the topical or transdermal delivery of drug-loaded nano/microsystems.
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Lívia Neves Borgheti-Cardoso, Tamara Ângelo, Guilherme M. Gelfuso, Renata F.V. Lopez, Taís Gratieri , Topical and Transdermal Delivery of Drug-Loaded Nano/ Microsystems with Application of Physical Enhancement Techniques, Current Drug Targets 2016; 17 (13) . https://dx.doi.org/10.2174/1389450116666151019095121
DOI https://dx.doi.org/10.2174/1389450116666151019095121 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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