Hybrid Bioactive Heterocycles as Potential Antimicrobial Agents: A Review

Title:Hybrid Bioactive Heterocycles as Potential Antimicrobial Agents: A Review

Volume: 16 Issue: 18

Author(s): Nisheeth Desai, Amit Trivedi, Unnat Pandit, Amit Dodiya, V. Kameswara Rao and Priyanka Desai

Affiliation:

Keywords: Antimicrobial agents, benzimidazole, bioactive heterocycles, hybrid molecules, 4-thiazolidinone, quinoline.

Abstract: The ever increasing cases of microbial resistance pose a major threat to the scientific community and therefore the need for discovery and development of newer antimicrobial agents with novel mode of action is becoming critical. One of the ways to tackle this herculean problem is to generate hybrid molecules by combining two or more bioactive heterocyclic moieties in a single molecular platform. The review here describes published results of our research group’s endeavors towards development of potential new and safe antimicrobial agents with better effectiveness by using the hybrid approach. In the present review article the landscaping of heterocycles like 4-thiazolidinones, benzimidazole and quinoline are described. Compounds displaying two of more fold antimicrobial activity are included in the review.

Cite this article as:

Desai Nisheeth, Trivedi Amit, Pandit Unnat, Dodiya Amit, Rao Kameswara V. and Desai Priyanka, Hybrid Bioactive Heterocycles as Potential Antimicrobial Agents: A Review, Mini-Reviews in Medicinal Chemistry 2016; 16 (18) . https://dx.doi.org/10.2174/1389557516666160609075620