针对肿瘤治疗的促胃液素释放肽受体：新兴的信号网络和治疗应用

Title:Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications

Volume: 17 Issue: 5

Author(s): Mikko O. Laukkanen and Maria Domenica Castellone

Affiliation:

关键词: 肿瘤，神经肽，信号转导，药物靶标，临床试验。

摘要: Growth factors of the bombesin/gastrin releasing peptide (BN/GRP) family play a critical role in proliferation and progression of malignancies. Inhibitors targeting GRP signalling have been developed and tested as anticancer compounds showing promising preclinical and early phase clinical results. In this review, we will discuss the molecular signaling, expression and the functional role of BN/GRP-GRPR in different cancer models and will focus on the available strategies to target BN/GRP-GRPR in cancer treatment as well as in tumour diagnosis and follow up.

Cite this article as:

Mikko O. Laukkanen and Maria Domenica Castellone , Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications, Current Drug Targets 2016; 17 (5) . https://dx.doi.org/10.2174/1389450116666151001112130