黄芪根（黄芪和相关种）在保护组织免受损伤和病变的抗氧化作用

Title:The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease

Volume: 17 Issue: 12

Author(s): Muhammad Shahzad, Arham Shabbir, Ken Wojcikowski, Hans Wohlmuth, Glenda C. Gobe

Affiliation:

关键词: 黄芪属，黄芪，抗氧化剂，黄芪总苷，心血管保护，缺血-再灌注，肾保护

摘要: Oxidative stress plays a key role in the pathogenesis of various diseases. Antioxidants protect the cells and tissues from oxidative stress by scavenging free radicals and reactive oxygen species. These antioxidants may be endogenous or exogenous. Plants are considered as potential and powerful exogenous source of antioxidants. Astragalus species (spp.), especially Astragalus membranaceus, have a long history of medicinal use in traditional Chinese medicine. Specifically, constituents of the dried roots of Astragalus spp. (Radix Astragali) provide significant protection against heart, brain, kidney, intestine, liver and lung injury in various models of oxidative stress-related disease. Different isolated constituents of Astragalus spp., such as astragalosides, flavonoids and polysaccharides also displayed significant prevention of tissue injury via antioxidant mechanisms. In this article, the antioxidant benefits of Astragalus spp. and its isolated components in protecting tissues from injury are reviewed, along with identification of the various constituents that possess antioxidant activity.

Cite this article as:

Muhammad Shahzad, Arham Shabbir, Ken Wojcikowski, Hans Wohlmuth, Glenda C. Gobe , The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease, Current Drug Targets 2016; 17 (12) . https://dx.doi.org/10.2174/1389450116666150907104742