The Role of Bioreactors in Ligament and Tendon Tissue Engineering

Title:The Role of Bioreactors in Ligament and Tendon Tissue Engineering

Volume: 11 Issue: 1

Author(s): James Mace, Andy Wheelton, Wasim S. Khan and Sanj Anand

Affiliation:

Keywords: Bioreactors, flow perfusion, ligament, rotating wall, spinner flasks, tendon.

Abstract: Bioreactors are pivotal to the emerging field of tissue engineering. The formation of neotissue from pluripotent cell lineages potentially offers a source of tissue for clinical use without the significant donor site morbidity associated with many contemporary surgical reconstructive procedures. Modern bioreactor design is becoming increasingly complex to provide a both an expandable source of readily available pluripotent cells and to facilitate their controlled differentiation into a clinically applicable ligament or tendon like neotissue. This review presents the need for such a method, challenges in the processes to engineer neotissue and the current designs and results of modern bioreactors in the pursuit of engineered tendon and ligament.

Cite this article as:

Mace James, Wheelton Andy, Khan S. Wasim and Anand Sanj, The Role of Bioreactors in Ligament and Tendon Tissue Engineering, Current Stem Cell Research & Therapy 2016; 11 (1) . https://dx.doi.org/10.2174/1574888X10666150904113827