Monocytes, Macrophages and Other Inflammatory Mediators of Abdominal Aortic Aneurysm

Title:Monocytes, Macrophages and Other Inflammatory Mediators of Abdominal Aortic Aneurysm

Volume: 21 Issue: 28

Author(s): Stephane Potteaux and Alain Tedgui

Affiliation:

Keywords: Monocyte, macrophage, migration, chemokine, cytokine, aneurysm, spleen, lymphocytes.

Abstract: Macrophages early invade the forming abdominal aortic aneurysm (AAA) and greatly contribute to its pathogenesis. Recent findings have shown that Ly-6C^high and Ly-6C^low monocytes are rapidly mobilized from the splenic reservoir in response to angiotensin II infusion and sequentially infiltrate the abdominal aorta. The first wave of Ly-6C^high monocytes prevails in the aorta and promotes the accumulation of inflammatory macrophages, which most likely cause irreversible changes in the abdominal aorta. In this review, we discuss the current knowledge on the cellular mechanisms that initiate AAA in mice. We particularly focus on the role of monocyte and macrophage subsets during the early steps of the aneurysmal process.

Cite this article as:

Potteaux Stephane and Tedgui Alain, Monocytes, Macrophages and Other Inflammatory Mediators of Abdominal Aortic Aneurysm, Current Pharmaceutical Design 2015; 21 (28) . https://dx.doi.org/10.2174/1381612821666150826093855