HIV-1 Tat和艾滋病发病机制中的免疫失调：治疗靶点

Title:HIV-1 TAT and IMMUNE DYSREGULATION in AIDS PATHOGENESIS: a THERAPEUTIC TARGET

Volume: 17 Issue: 1

Author(s): Chiara Chiozzini and Elena Toschi

Affiliation:

关键词: AIDS发病机制，免疫失调，HIV-1， Tat，治疗，疫苗。

摘要: The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates expression of viral and cellular genes and it modulates several cellular pathways leading to HIV-1 infection spreading and immune dysregulation. So far, Tat protein and the cellular pathways targeted by Tat may represent potential targets for new anti-HIV therapeutic approaches and vaccine development against AIDS.

Cite this article as:

Chiara Chiozzini and Elena Toschi , HIV-1 TAT and IMMUNE DYSREGULATION in AIDS PATHOGENESIS: a THERAPEUTIC TARGET, Current Drug Targets 2016; 17 (1) . https://dx.doi.org/10.2174/1389450116666150825110658