抗结核药物发现研究进展：潜在原型和新的目标

Title:Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets

Volume: 22 Issue: 27

Author(s): Guilherme Felipe dos Santos Fernandes, Daniela Hartmann Jornada, Paula, Carolina de Souza, Chung Man Chin and Fernando Rogerio Pavan and Jean Leandro dos Santos

Affiliation:

关键词: 抗结核药物，药物发现，结核分枝杆菌耐药结核，肺结核，肺结核靶点。

摘要: Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to substantially reduce the number of cases in the coming years; however, the increased number of multidrug-resistant (MDR) and extremely drug-resistant (XDR) forms of the bacterium and the lack of treatment for latent tuberculosis are challenges to be overcome. In this review, we have identified the most potent compounds described in the literature during recent years with MIC values < 7 µM, low toxicity and a high selective index. In addition, emerging targets in MTB are presented to provide new perspectives for the discovery of new antitubercular drugs. This review aims to summarize the current advances in and promote insights into antitubercular drug discovery.

Cite this article as:

Guilherme Felipe dos Santos Fernandes, Daniela Hartmann Jornada, Paula, Carolina de Souza, Chung Man Chin and Fernando Rogerio Pavan and Jean Leandro dos Santos , Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets, Current Medicinal Chemistry 2015; 22 (27) . https://dx.doi.org/10.2174/0929867322666150818103836