Anti-inflammatory Activities of Phenoxyphenyl Ureas Mediated by Inhibition of p38 Kinase

Title:Anti-inflammatory Activities of Phenoxyphenyl Ureas Mediated by Inhibition of p38 Kinase

Volume: 11 Issue: 2

Author(s): Ravindra Kulkarni, Swapna Diwyani, Stefan Laufer, Chandrshekar V. M., Achaiah G., Prashant Gurav and Prasanna Habbu

Affiliation:

Keywords: Anti-inflammatory, diphenyl urea, p38 kinase, synthesis/in vitro/in vivo.

Abstract: P38 kinase has been known to be one of the important and validated targets for inflammatory diseases including rheumatoid arthritis for its vital role in production and release of proinflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin-beta (IL-1β). Pyridinyl group of our reported compounds was replaced by simple phenyl groups and compounds were synthesized and characterized. A dose of 50 mg/Kg has been administered and observed antiinflammatory activity in rats. Compounds 6h, 6i, 6j and 6o exhibited significant antiinflammatory activity at 3^rd hour of carrageenan administration. Compounds 6c, 6j, 6k and others demonstrated greater than 50% p38 kinase inhibitory activity at 10 μM.

Cite this article as:

Kulkarni Ravindra, Diwyani Swapna, Laufer Stefan, V. M. Chandrshekar, G. Achaiah, Gurav Prashant and Habbu Prasanna, Anti-inflammatory Activities of Phenoxyphenyl Ureas Mediated by Inhibition of p38 Kinase, Current Enzyme Inhibition 2015; 11 (2) . https://dx.doi.org/10.2174/1573408011666150729221843