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Current Immunology Reviews (Discontinued)

Editor-in-Chief

ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

Mechanisms of Inflammatory Atherosclerosis in Rheumatoid Arthritis

Author(s): Zoltan Szekanecz, Gyorgy Kerekes, Zsofia Kardos, Zsuzsa Barath and Laszlo Tamasi

Volume 12, Issue 1, 2016

Page: [35 - 46] Pages: 12

DOI: 10.2174/1573395511666150706181454

Price: $65

Abstract

Cardiovascular disease dependent on inflammatory accelerated atherosclerosis leads to increased mortality in rheumatoid arthritis (RA). In addition to traditional, Framingham risk factors, several immuno-inflammatory cells, mediators and molecules may link atherosclerosis to arthritis. Among immune cells, primarily TH1 cells, as well as endothelial cells play a crucial role in synovial and vascular inflammation. Various cell surface molecules, such as adhesion receptors, CD40-CD40 ligand or members of the RANK-RANK ligand-osteoprotegerin system, as well as soluble pro-inflammatory cytokines, chemokines, autoantibodies and proteases have been implicated in RA and vascular damage. The early assessment of atherosclerosis and early intervention would decrease cardiovascular risk in RA.

Keywords: Atherosclerosis, biologics, cardiovascular disease, chemokines, cytokines, DMARDs, endothelial cells, proteases, RANK ligand, rheumatoid arthritis.


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