富含水飞蓟素口服制剂治疗肝损伤(尤其是NAFLD)的优缺点

Title:The Pros and the Cons for the Use of Silybin-Rich Oral Formulations in Treatment of Liver Damage (NAFLD in Particular)

Volume: 22 Issue: 25

Author(s): Natalia Rosso, Veronica Marin, Antonio Giordani, Stefano Persiani, Federica Sala, Lucio Cavicchioli, Lucio C. Rovati and Claudio Tiribelli

Affiliation:

关键词: 细胞凋亡，纤维化，炎症，胰岛素抵抗氧化应激，水飞蓟素，脂肪变性。

摘要: The increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) worldwide is becoming a challenge for the modern global care system. The lipotoxic process is characterized by an oxidative stress followed by a burst of the inflammatory response, prompting the wound healing process (fibrosis), which can ultimately lead to the development of cirrhosis and the subsequent complications. There is no consensus concerning an effective pharmacological treatment. Therefore, there is a need for effective therapeutic compounds. Silibinin the major active compound of Milk Thistle may be a potential candidate mainly due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties. In spite of the large number of data obtained in experimental models, the translation of the evidence in clinical setting is far to be conclusive. The aim of this paper is to critically review the aspects of the use of the different formulations of Silibinin in several experimental and clinical settings and to provide hints on the needed future studies.

Cite this article as:

Natalia Rosso, Veronica Marin, Antonio Giordani, Stefano Persiani, Federica Sala, Lucio Cavicchioli, Lucio C. Rovati and Claudio Tiribelli , The Pros and the Cons for the Use of Silybin-Rich Oral Formulations in Treatment of Liver Damage (NAFLD in Particular), Current Medicinal Chemistry 2015; 22 (25) . https://dx.doi.org/10.2174/0929867322666150729114235