PPARγ and Its Ligands: Potential Antitumor Agents in the Digestive System

Title:PPARγ and Its Ligands: Potential Antitumor Agents in the Digestive System

Volume: 11 Issue: 3

Author(s): Linjing Shu, Renhuan Huang, Songtao Wu, Zhaozhao Chen, Ke Sun, Yan Jiang and Xiaoxiao Cai

Affiliation:

Keywords: Antitumor, chemoprevention, digestive system, peroxisome proliferator-activated receptor γ, thiazolidinediones (TZDs), tumor cells.

Abstract: Peroxisome proliferator-activated receptor γ (PPARγ) is a versatile member of the ligandactivated nuclear hormone receptor superfamily of transcription factors, with expression in several different cell lines, especially in the digestive system. After being activated by its ligand, PPARγ can suppress the growth of oral, esophageal, gastric, colorectal, liver, biliary, and pancreatic tumor cells, suggesting that PPARγ ligand is a potential anticancer agent in PPARγ-expressing tumors. This review highlights key advances in understanding the effects of PPARγ ligands in the treatment of tumors in the digestive system.

Cite this article as:

Shu Linjing, Huang Renhuan, Wu Songtao, Chen Zhaozhao, Sun Ke, Jiang Yan and Cai Xiaoxiao, PPARγ and Its Ligands: Potential Antitumor Agents in the Digestive System, Current Stem Cell Research & Therapy 2016; 11 (3) . https://dx.doi.org/10.2174/1574888X10666150630111618