Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives

Title:Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives

Volume: 12 Issue: 8

Author(s): Takuma Yoshida, Lei Wang, Shiori Nakagawa, Zetryana Puteri Tachrim, Yasuko Sakihama, Yasuyuki Hashidoko and Makoto Hashimoto

Affiliation:

Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.

Abstract: Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the construction of diketopiperazine skeleton.

Cite this article as:

Yoshida Takuma, Wang Lei, Nakagawa Shiori, Tachrim Puteri Zetryana, Sakihama Yasuko, Hashidoko Yasuyuki and Hashimoto Makoto, Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives, Letters in Organic Chemistry 2015; 12 (8) . https://dx.doi.org/10.2174/1570178612666150629181357