Deoxyribozymes as Inhibitors of Vascular Smooth Muscle Cell Growth

Title: Deoxyribozymes as Inhibitors of Vascular Smooth Muscle Cell Growth

Volume: 5 Issue: 4

Author(s): Levon M. Khachigian

Affiliation:

Keywords: dnazymes, post-angioplasty restenosis, egr-1

Abstract: DNA enzymes, or DNAzymes, are all-DNA molecules with inherent catalytic activity that bind and cleave at their complementary sequence in the target mRNA through Watson-Crick base pairing. These agents have been successfully used to tease out the role the targeted gene plays in both cellular systems and in a variety of animal models. DNAzymes have the potential to serve as novel nucleic acid-based therapeutic agents in pathologies involving aberrant smooth muscle cell growth and a range of other disorders.

Cite this article as:

Khachigian M. Levon, Deoxyribozymes as Inhibitors of Vascular Smooth Muscle Cell Growth, Current Pharmaceutical Biotechnology 2004; 5 (4) . https://dx.doi.org/10.2174/1389201043376788