Development of Global Consensus of Dengue Virus Envelope Glycoprotein for Epitopes Based Vaccine Design

Title:Development of Global Consensus of Dengue Virus Envelope Glycoprotein for Epitopes Based Vaccine Design

Volume: 11 Issue: 1

Author(s): Mazhar Hussain, Muhammad Idrees and Samia Afzal

Affiliation:

Keywords: Dengue virus, consensus sequence, Envelope glycoprotein, phylogenetic analysis, in silico design.

Abstract: Dengue virus (DENV) is the member of Flaviviridae and causative agent of Dengue Haemorrhagic Fever and Dengue Shock Syndrome. Every year, around 70% of the world population is at risk, due to epidemic episodes orchestrated by one or more of its serotypes. So, a tetravalent DENV vaccine is needed which may induce the immune response against all four DENV serotypes. In this study, B-cell and T-cell epitopes have been predicted from the DENV envelope glycoprotein (E_g) using a consensus based approach in complement with the physico-chemical property (PCP) conservancy analysis. Through DENV-Eg analysis, a total of 7 PCP conserved, water soluble, in vitro and in vivo stable epitopes were predicted which may induce the B-cell and T-cell mediated anti-viral immune response.

Cite this article as:

Hussain Mazhar, Idrees Muhammad and Afzal Samia, Development of Global Consensus of Dengue Virus Envelope Glycoprotein for Epitopes Based Vaccine Design, Current Computer-Aided Drug Design 2015; 11 (1) . https://dx.doi.org/10.2174/1573409911666150529130134