Nano Clinoptilolite: Highly Efficient Catalyst for the Synthesis of Chromene Derivatives Under Solvent-Free Conditions

Title:Nano Clinoptilolite: Highly Efficient Catalyst for the Synthesis of Chromene Derivatives Under Solvent-Free Conditions

Volume: 18 Issue: 5

Author(s): Sara Hallajian, Mohammad A. Khalilzadeh, Mahgol Tajbakhsh, Eskandar Alipour and Zahra Safaei

Affiliation:

Keywords: 4-hydroxycoumarin, acetylenic compounds, N-nucleophiles, solvent-free.

Abstract: An efficient and selective synthesis of substituted chromene derivatives via threecomponent reaction of 4-hydroxycoumarin or 1,3-dicarbonyl compounds, activated acetylenic compounds and N-nucleophiles is described. The reaction was conducted under solvent-free conditions at 70°C using potassium fluoride impregnated on natural zeolite as a cheap and available solid base. The procedure has several advantages involving selectivity, excellent yields and a convenient work-up method.

Cite this article as:

Hallajian Sara, Khalilzadeh A. Mohammad, Tajbakhsh Mahgol, Alipour Eskandar and Safaei Zahra, Nano Clinoptilolite: Highly Efficient Catalyst for the Synthesis of Chromene Derivatives Under Solvent-Free Conditions, Combinatorial Chemistry & High Throughput Screening 2015; 18 (5) . https://dx.doi.org/10.2174/1386207318666150424104452