甲氨蝶呤对类风湿关节炎患者的心血管效应再探

Title:Cardiovascular Effects of Methotrexate in Rheumatoid Arthritis Revisited

Volume: 22 Issue: 16

Author(s): Tatyana V. Popkova, Diana S. Novikova, Armen Yuri Gasparyan and Evgeny L. Nasonov

Affiliation:

关键词: 动脉粥样硬化，心血管疾病，炎症，甲氨蝶呤，类风湿性关节炎。

摘要: Cardiovascular events such as myocardial infarction (MI) and stroke due to enhanced inflammatory atherosclerosis account for increased premature mortality in rheumatoid arthritis (RA). Accumulated evidence suggests that accelerated atherosclerosis and related cardiovascular comorbidities in RA are confounded not only by traditional risk factors (TRF) but also by a number of immune and inflammatory pathways. Since chronic inflammation and autoimmune disorders play a key role in atherosclerosis and related cardiovascular complications in RA, effective suppression of systemic inflammation can be viewed as a strategy for cardiovascular therapy and prevention in this disease. This article overviews some mechanisms of action of methotrexate on TRF, clinical and subclinical manifestations of RA-induced atherosclerosis, and related cardiovascular morbidity and mortality.

Cite this article as:

Tatyana V. Popkova, Diana S. Novikova, Armen Yuri Gasparyan and Evgeny L. Nasonov , Cardiovascular Effects of Methotrexate in Rheumatoid Arthritis Revisited, Current Medicinal Chemistry 2015; 22 (16) . https://dx.doi.org/10.2174/0929867322666150415122039