Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation

Title:Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation

Volume: 16 Issue: 11

Author(s): Hans Hendrik Schafer, Thomas Dieterle, Aaron Trachsler, Mikael Gencay and Edelgard Anna

Affiliation:

Keywords: Corticosteroid-steroid binding, drug, glucocorticoids, heart, humans, mineralocorticoids.

Abstract: Corticosteroid (glucocorticoids [GCs] and mineralcorticoids [MCs]) interact directly with cells of the cardiovascular system. Their signaling affects genomic and non-genomic receptors and comprises a multitude of alternative and interfering levels of interaction, which influence the physiological response. This review describes genomic and non-genomic pathways of steroid facilitation and portrays the current body of knowledge regarding corticosteroid-binding globulin (CBG). The latter is a carrier protein facilitating corticosteroid availability in the circulation and has recently been discovered intrinsically in cardiomyocytes. Thought experiments highlight potential areas of clinical research and hypotheses are presented for steroid- carrier interaction. Furthermore, this review comprises a conclusive overview of disease conditions and substances that influence CBG levels and summarizes the potential of CBG as a potential future biomarker.

Cite this article as:

Hendrik Schafer Hans, Dieterle Thomas, Trachsler Aaron, Gencay Mikael and Anna Edelgard, Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation, Current Drug Targets 2015; 16 (11) . https://dx.doi.org/10.2174/1389450116666150408103806