骨转移癌显像的纳米放射性药物

Title:Nanoradiopharmaceuticals for Bone Cancer Metastasis Imaging

Volume: 15 Issue: 5

Author(s): Bianca Feliciano Coelho, Marta de Souza Albernaz, Alexandre Iscaife, Katia Ramos Moreira Leite and Mara de Souza Junqueira, Emerson Soares Bernardes, Emerson Oliveira da Silva and Ralph Santos-Oliveira

Affiliation:

关键词: 骨，纳米技术，肿瘤，放射性药物。

摘要: Drug delivery systems are under intense investigation all around the world, especially in oncology research. Indeed, in some cases, like bone metastasis, nanodrugs may represent the last and best choice for both treatment and imaging of early cancer foci. Nuclear medicine has been using MDP labelled with 99mTc as radiopharmaceuticals for many years; however, their use as nanoradiopharmaceuticals is very innovative and creates a new way to establish radiopharmacy in this new scenario offered by nanotechnology. In this study we developed and tested nano-MDP-labelled with 99mTc in rats induced with bone cancer metastasis and the results showed that it may work in patients. However, some further experiments are required in order to initiate protocols in humans.

Cite this article as:

Bianca Feliciano Coelho, Marta de Souza Albernaz, Alexandre Iscaife, Katia Ramos Moreira Leite and Mara de Souza Junqueira, Emerson Soares Bernardes, Emerson Oliveira da Silva and Ralph Santos-Oliveira , Nanoradiopharmaceuticals for Bone Cancer Metastasis Imaging, Current Cancer Drug Targets 2015; 15 (5) . https://dx.doi.org/10.2174/1568009615666150407125020