Nerve Growth Factor: A Focus on Neuroscience and Therapy

Title:Nerve Growth Factor: A Focus on Neuroscience and Therapy

Volume: 13 Issue: 3

Author(s): Luigi Aloe, Maria Luisa Rocco, Bijorn Omar Balzamino and Alessandra Micera

Affiliation:

Keywords: Clinical trials, NGF, NGF-healing action, treatment, NGF receptors, visual system.

Abstract: Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis outgrowth both in vivo and in vitro and nerve cell recovery after ischemic, surgical or chemical injuries. Recently, the therapeutic property of NGF has been demonstrated on human cutaneous and corneal ulcers, pressure ulcer, glaucoma, maculopathy and retinitis pigmentosa. NGF eye drops administration is well tolerated, with no detectable clinical evidence of systemic or local adverse effects. The aim of this review is to summarize these biological properties and the potential clinical development of NGF.

Cite this article as:

Aloe Luigi, Rocco Luisa Maria, Balzamino Omar Bijorn and Micera Alessandra, Nerve Growth Factor: A Focus on Neuroscience and Therapy, Current Neuropharmacology 2015; 13 (3) . https://dx.doi.org/10.2174/1570159X13666150403231920