氧化剂/抗氧化剂失衡和阿尔茨海默氏症的风险

Title:Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease

Volume: 12 Issue: 4

Author(s): Ahmed E. Abdel Moneim

Affiliation:

关键词: 阿尔茨海默氏症；抗氧化剂；氧化应激。

摘要: Alzheimer's disease (AD) is the most common form of dementia characterized by progressive loss of memory and other cognitive functions among older people. Senile plaques and neurofibrillary tangles are the most hallmarks lesions in the brain of AD in addition to neurons loss. Accumulating evidence has shown that oxidative stress–induced damage may play an important role in the initiation and progression of AD pathogenesis. Redox impairment occurs when there is an imbalance between the production and quenching of free radicals from oxygen species. These reactive oxygen species augment the formation and aggregation of amyloid-β and tau protein hyperphosphorylation and vice versa. Currently, there is no available treatments can modify the disease. However, wide varieties of antioxidants show promise to delay or prevent the symptoms of AD and may help in treating the disease. In this review, the role of oxidative stress in AD pathogenesis and the common used antioxidant therapies for AD will summarize.

Cite this article as:

Ahmed E. Abdel Moneim , Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease, Current Alzheimer Research 2015; 12 (4) . https://dx.doi.org/10.2174/1567205012666150325182702