Targeting microRNAs in Pathological Hypertrophy and Cardiac Failure

Title:Targeting microRNAs in Pathological Hypertrophy and Cardiac Failure

Volume: 15 Issue: 6

Author(s): Dongchao Lv, Jingqi Liu, Cuimei Zhao, Qi Sun, Qiulian Zhou, Jiahong Xu and Junjie Xiao

Affiliation:

Keywords: Cardiac failure, microRNA, pathological hypertrophy, therapy.

Abstract: MicroRNAs (miRNAs) are a novel class of endogenous, short, non-coding, posttranscriptional RNAs, which play important roles in regulating lots of important biological functions. Evidences show that altered expression of miRNAs are involved in pathological hypertrophy and cardiac failure, making it possible to target miRNAs as a novel therapy. In this review, we focus on very recent progresses in the regulation of miRNAs in pathological hypertrophy and cardiac failure. In addition, we also discuss the potential of using miRNAs as a new therapy for pathological hypertrophy and cardiac failure.

Cite this article as:

Lv Dongchao, Liu Jingqi, Zhao Cuimei, Sun Qi, Zhou Qiulian, Xu Jiahong and Xiao Junjie, Targeting microRNAs in Pathological Hypertrophy and Cardiac Failure, Mini-Reviews in Medicinal Chemistry 2015; 15 (6) . https://dx.doi.org/10.2174/1389557515666150324124751