精神障碍的微内表型：精神疾病在分子动力学、突触、神经元、神经环路水平上的表型

Title:Microendophenotypes of Psychiatric Disorders: Phenotypes of Psychiatric Disorders at the Level of Molecular Dynamics, Synapses, Neurons, and Neural Circuits

Volume: 15 Issue: 2

Author(s): S. Kida and T. Kato

Affiliation:

关键词: 动物模型，抑郁狂躁型忧郁症，抑郁症，内表型，微内表型，精神障碍，创伤后精神紧张性精神障碍，精神分裂症

摘要: Psychiatric disorders are caused not only by genetic factors but also by complicated factors such as environmental ones. Moreover, environmental factors are rarely quantitated as biological and biochemical indicators, making it extremely difficult to understand the pathological conditions of psychiatric disorders as well as their underlying pathogenic mechanisms. Additionally, we have actually no other option but to perform biological studies on postmortem human brains that display features of psychiatric disorders, thereby resulting in a lack of experimental materials to characterize the basic biology of these disorders. From these backgrounds, animal, tissue, or cell models that can be used in basic research are indispensable to understand biologically the pathogenic mechanisms of psychiatric disorders. In this review, we discuss the importance of microendophenotypes of psychiatric disorders, i.e., phenotypes at the level of molecular dynamics, neurons, synapses, and neural circuits, as targets of basic research on these disorders.

Cite this article as:

S. Kida and T. Kato , Microendophenotypes of Psychiatric Disorders: Phenotypes of Psychiatric Disorders at the Level of Molecular Dynamics, Synapses, Neurons, and Neural Circuits, Current Molecular Medicine 2015; 15 (2) . https://dx.doi.org/10.2174/1566524015666150303002128