Solvent-Drop Grinding Method: Efficient Synthesis, DPPH Radical Scavenging and Anti-diabetic Activities of Chalcones, bis-chalcones, Azolines, and bis-azolines

Title:Solvent-Drop Grinding Method: Efficient Synthesis, DPPH Radical Scavenging and Anti-diabetic Activities of Chalcones, bis-chalcones, Azolines, and bis-azolines

Volume: 12 Issue: 2

Author(s): Sobhi M. Gomha, Sayed M. Riyadh*Mohamed M. Abdalla

Affiliation:

• Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613,Egypt

Keywords: Anti-diabetic activity, antioxidant activity, bis-isoxazolines, bis-pyrazolines, enones, isoxazolines, pyrazolines, solvent-free grinding.

Abstract: Highly efficient one-pot solvent-free grinding method was reported for synthesis of chalcones 3a-j, 5a,b, 7 and bis-chalcones 9, 11. Cyclodehydration of bis-chalcones 9, 11 and chalcones 3 with hydrazine derivatives under solvent- free grinding method afforded bis-pyrazolines 12a,b, 13a,b and pyrazoline derivatives 14a-g, respectively. In a similar manner, grinding of bis-chalcones 9, 11 and chalcones 3 with hydroxylamine hydrochloride under the employed reaction conditions gave bis-isoxazolines 15, 16 and isoxazoline derivatives 17a-e, respectively. The antioxidant activity of the selected products was studied using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay. Also, the antidiabetic activity of the selected products against normal and alloxan induced diabetic mice was evaluated.

Cite this article as:

Gomha M. Sobhi, Riyadh M. Sayed*, Abdalla M. Mohamed, Solvent-Drop Grinding Method: Efficient Synthesis, DPPH Radical Scavenging and Anti-diabetic Activities of Chalcones, bis-chalcones, Azolines, and bis-azolines, Current Organic Synthesis 2015; 12 (2) . https://dx.doi.org/10.2174/1570179412666150122230447